Dabigatran Plasma Measurement to Guide the Management of Acute Bleeding and Thrombotic Complications

Tala, Maurizio and Paoletti, Oriana and Dellanoce, Claudia and Morandini, Rossella and Valtulina, Carlo and Sessa, Maria and Testa, Sophie (2018) Dabigatran Plasma Measurement to Guide the Management of Acute Bleeding and Thrombotic Complications. European Journal of Case Reports in Internal Medicine, 5 (9). ISSN 2284-2594

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Oral anticoagulant therapy is recommended for the prevention and treatment of venous thromboembolism and to prevent stroke in non-valvular atrial fibrillation. Until a few years ago, vitamin K antagonists were the only drugs available, but direct oral anticoagulants have recently been introduced into clinical practice for the same clinical indications. Unlike the situation with VKAs, fixed-dose administration was proposed for DOACs, without the necessity for routine laboratory monitoring. However, in clinical practice a high inter-variability in DOAC plasma levels, independently of the type of drug and patient characteristics, was observed and the importance of measuring DOAC anticoagulant activity to support treatment decisions has therefore been recognized. We describe two clinical cases in order to highlight the role and importance of dabigatran-specific measurements to guide patient management in case of major complications.

Item Type: Article
Uncontrolled Keywords: DOACs, dabigatran, anticoagulant, plasma measurement, idarucizumab
Subjects: 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale)
Depositing User: Greta Di Blasio
Date Deposited: 11 Jun 2019 10:52
Last Modified: 11 Jun 2019 10:52
URI: http://eprints.bice.rm.cnr.it/id/eprint/18776

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