Serpa, Maria João Raposo Linhares and Falcão, Luís and Franco, Susana and Repolho, Diana and Ferreira, Nuno Ribeiro (2018) Metabolic Acidosis Due To Pyroglutamic Acid. European Journal of Case Reports in Internal Medicine, 5 (10). ISSN 2284-2594
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Abstract
Metabolic acidosis is a common clinical disturbance due to increased plasma acidity caused by a primary decrease in serum HCO3- concentration. It is classified as normal or high anion gap metabolic acidosis. High anion gap metabolic acidosis can result from either a decrease in unmeasured cations (K+, Ca2+, Mg2+) or an increase in unmeasured anions (PO43-, albumin). However, other anions such as lactic acid or keto acids may cause this acid-base disorder. It can also result from renal failure and intoxication (salicylate, methanol, ethylene glycol), or more rarely, from massive rhabdomyolysis and pyroglutamic (5-oxoproline) acidemia. Acidemia due to pyroglutamic acid should be considered when no other aetiology is found. High anion gap metabolic acidosis is diagnosed in children with inherited defects in enzymes of the γ-glutamyl cycle. In adults, this disorder from pyroglutamic acid has been described in association with chronic acetaminophen misuse. We report a case of pyroglutamic acidosis in a woman with acute misuse of acetaminophen concurrent with chronic use.
| Item Type: | Article |
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| Uncontrolled Keywords: | High anion gap metabolic acidosis, 5-oxoprolinemia, pyroglutamic acidemia, acetaminophen, paracetamol |
| Subjects: | 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) |
| Depositing User: | Greta Di Blasio |
| Date Deposited: | 11 Jun 2019 10:47 |
| Last Modified: | 11 Jun 2019 10:47 |
| URI: | http://eprints.bice.rm.cnr.it/id/eprint/18781 |
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