Systemic Amyloidosis with Renal Failure: A Challenging Diagnosis of SAPHO Syndrome

Pires Correia, Cristina and Martins, António and Oliveira, Jorge and Andrade, Sérgio and Almeida, Jorge (2019) Systemic Amyloidosis with Renal Failure: A Challenging Diagnosis of SAPHO Syndrome. European Journal of Case Reports in Internal Medicine, 6 (4). ISSN 2284-2594

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Synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome is a rare, unrecognized and chronic inflammatory disorder characterized by distinct cutaneous and osteoarticular manifestations. Renal complications are uncommon. We describe the unusual case of a patient with severe refractory and chronic hidradenitis suppurativa (HS) that progressed to chronic renal failure due to secondary amyloidosis, presenting with mandibular pain and renal failure. The challenging diagnosis of SAPHO syndrome was made. The purpose of this case report is to emphasize the need for vigilance, timely recognition and multidisciplinary treatment. The fundamental management of AA amyloidosis and SAPHO syndrome requires an individualized approach with control of the underlying inflammatory disease.

Item Type: Article
Uncontrolled Keywords: AA amyloidosis, SAPHO syndrome, hidradenitis suppurativa
Subjects: 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale)
Depositing User: Chiara D'Arpa
Date Deposited: 10 Jun 2019 14:41
Last Modified: 10 Jun 2019 14:41

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