Lenalidomide: An Alternative Treatment for Refractory Behçet’s Disease and Relapsing Polychondritis

Brazao, Sofia Gomes and Crespo, Jorge and Carvalho, Armando (2019) Lenalidomide: An Alternative Treatment for Refractory Behçet’s Disease and Relapsing Polychondritis. European Journal of Case Reports in Internal Medicine, 6 (6). ISSN 2284-2594

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Introduction:Behçet’s disease (BD) is a chronic systemic condition characterized by recurrent oral and genital ulcers, neurological and vascular manifestations, ocular and skin lesions, and a positive pathergy test. Mouth and genital ulcers with inflamed cartilage (MAGIC) syndrome is rare and consists of features of BD together with relapsing polychondritis. The treatment of this syndrome is similar that of BD and depends on disease expression and symptoms. Case Report: We report the case of a 50-year-old man diagnosed with BD with relapsing polychondritis (MAGIC syndrome) which had evolved over approximately 35 years, with exuberant and frequent oral and genital ulcers. Various treatments were unsuccessful and had adverse effects. Lenalidomide was initiated at a dose of 5 mg per day with remission of oral and genital ulcers and no haematological or adverse effects. Conclusion: BD is a complex disorder with a variety of presentations. Its treatment can be challenging but sometimes off-label drugs, like lenalidomide, can be effective.

Item Type: Article
Uncontrolled Keywords: Behçet’s disease, MAGIC syndrome, lenalidomide, aphtosis
Subjects: 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale)
Depositing User: Sr. Francesco Bonaccorsi
Date Deposited: 15 Jan 2020 09:31
Last Modified: 15 Jan 2020 09:31
URI: http://eprints.bice.rm.cnr.it/id/eprint/19422

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