Newman, C. and Connoly, S. and MacEneaney, O. and O'Keane, C. and McQuaid, S. E. (2019) Leydig Cell Hyperplasia Mimicking a Testicular Tumour in a Patient with Klinefelter Syndrome. European Journal of Case Reports in Internal Medicine, 6 (6). ISSN 2284-2594
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Abstract
Background: Klinefelter syndrome (KS) is the most common sex-chromosomal disorder in males. Frequently under-recognized, it occurs in 1 in 500–600 male births. It is caused by the inheritance of at least one additional X chromosome from either parent. Patients often have uncommon or atypical malignancies. Patient: We describe the case of a 35-year-old man with 47XXY KS and previous cryptorchidism, presenting with a painful testicular mass. Histology confirmed Leydig cell hyperplasia. Discussion: Cryptorchidism is an established risk factor for testicular tumours and occurs six times more commonly in KS than in the general population. Despite this, large epidemiological studies have shown a reduced burden of testicular cancer in these patients. The presentation of a hypoechoic lesion on ultrasound will prompt consideration of testicular tumours, however orchalgia represents an atypical presentation. In patients with KS, Leydig cell hyperplasia is a much more common entity and should be considered early in the differential diagnosis.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Leydig cell hyperplasia, Klinefelter syndrome |
| Subjects: | 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) |
| Depositing User: | Lorenzo Sgro |
| Date Deposited: | 28 Feb 2020 15:24 |
| Last Modified: | 28 Feb 2020 15:24 |
| URI: | http://eprints.bice.rm.cnr.it/id/eprint/19476 |
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