Bargiela, Inês and Gomes, Maria and Ferreira, Filipa and Ana Corte Real, Ana and Ventura, Ana (2019) A Rare Presentation of Ogilvie's Syndrome. European Journal of Case Reports in Internal Medicine, 6 (7). ISSN 2284-2594
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Abstract
Ogilvie’s syndrome or acute colonic pseudo-obstruction is characterized by massive colon dilation in the absence of mechanical obstruction or toxic megacolon. The phenotype associated with secretory diarrhoea is rare and is related to increased potassium channel activity in the colon, inducing excessive potassium loss, with increased sensitivity to normal serum aldosterone levels. The recommended therapy is potassium-sparing agents. We present the case of an 85-year-old patient who was admitted at the emergency department with prostration, abdominal distension and diarrhoea, corresponding to functional colonic dilation precipitated by severe hypokalaemia. Resolution of the condition only occurred after spironolactone was administered for suspected primary hyperaldosteronism, which was not proved as the patient showed normal aldosterone serum levels. The pathophysiological mechanism of abnormal potassium secretion in this scenario corresponds to ‘relative hyperaldosteronism’ caused by increased sensitivity of colonocytes to aldosterone.
| Item Type: | Article |
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| Uncontrolled Keywords: | Ogilvie’s syndrome, colonic pseudo-obstruction, hypokalemia, spironolactone |
| Subjects: | 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) |
| Depositing User: | Chiara D'Arpa |
| Date Deposited: | 18 Nov 2020 20:39 |
| Last Modified: | 18 Nov 2020 20:39 |
| URI: | http://eprints.bice.rm.cnr.it/id/eprint/19494 |
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