Maadarani, Ossama and Bitar, Zouhair and Mohsen, Mohammad (2019) Adding Herbal Products to Direct-Acting Oral Anticoagulants Can Be Fatal. European Journal of Case Reports in Internal Medicine, 6 (8). ISSN 2284-2594
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Abstract
Direct-acting oral anticoagulants (DOACs) are used to prevent and treat systemic and cerebral embolisms in patients with non-valvular atrial fibrillation (NV-AF). The use of DOACs with herbal products without consulting healthcare professionals increases the possibility of drug–herb interactions and their adverse effects. An 80-year-old man on dabigatran with a known history of NV-AF presented with a 1-day history of haematemesis and black stool which began 3 days after he had started taking a boiled mixture of ginger and cinnamon. The patient was hypotensive and treated as a case of gastrointestinal bleeding and haemorrhagic shock. Despite continuous aggressive resuscitation measures including administration of a reversal agent for dabigatran, we were unable to control bleeding and the patient died within 24 hours. The interaction of ginger and cinnamon with dabigatran led to fatal bleeding.
| Item Type: | Article |
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| Uncontrolled Keywords: | Ginger, cinnamon, dabigatran |
| Subjects: | 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) |
| Depositing User: | Chiara D'Arpa |
| Date Deposited: | 18 Nov 2020 20:41 |
| Last Modified: | 18 Nov 2020 20:41 |
| URI: | http://eprints.bice.rm.cnr.it/id/eprint/19499 |
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