Consider Nitrofurantoin as a Cause of Lung Injury

Almeida, Paulo and Seixas, Eduarda and Pinheiro, Beatriz and Ferreira, Pedro and Araújo, Ana (2019) Consider Nitrofurantoin as a Cause of Lung Injury. European Journal of Case Reports in Internal Medicine, 6 (11). ISSN 2284-2594

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Nitrofurantoin-induced diffuse lung toxicity is well documented in the literature but is often misdiagnosed. We describe an 82-year-old female medicated with nitrofurantoin for the previous 2 years who was admitted for dyspnoea, dry cough and fatigue for 4 months. She was febrile and tachypnoeic and she presented with bilateral basal crackles, hypoxaemic respiratory failure and slightly elevated C-reactive protein levels. A chest radiograph showed bilateral air-space consolidation and interstitial infiltrates and the high-resolution computed tomography scan was evocative of a perilobular pattern of organising pneumonia (OP). Due to the clinical–radiological context, she was diagnosed with a presumable nitrofurantoin-induced OP. She was started on prednisolone 60 mg daily with a progressive improvement. It is important that clinicians are aware of the spectrum of side effects associated with nitrofurantoin so as to monitor patients.

Item Type: Article
Uncontrolled Keywords: Nitrofurantoin, pulmonary toxicity, drug-induced lung toxicity, organising pneumonia
Subjects: 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale)
Depositing User: Chiara D'Arpa
Date Deposited: 19 Nov 2020 09:17
Last Modified: 19 Nov 2020 09:17

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