D’Arienzo, M. (2017) Dosimetry by 90Y internal pair production PET imaging after liver radioembolization: How well can we quantify the absorbed dose to lesions? Il nuovo cimento C, 40 (2). pp. 1-11. ISSN 1826-9885
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Abstract
Radioembolization is a catheter-based liver-directed therapy indicated mainly in a palliative setting for primary and secondary hepatic malignancies. It involves the administration of 90Y-loaded microspheres in the arterial vasculature of the liver by use of percutaneous transarterial techniques. Previous studies showed that the decay of 90Y has a minor branch to the 0+ first excited state of 90Zr at 1.76MeV, that is followed by a β+/β− emission. In recent years, a number of authors have used the small positronic emission of 90Y, (3.186±0.047)·10−5, to obtain highresolution positron emission tomography (PET) images of 90Y biodistribution after liver radioembolization. At present, it is generally accepted that the possibility of detecting β+ emissions from 90Y by PET scanners may pave the way for an accurate patient-specific dosimetry. The present paper has a twofold purpose. Firstly, a brief overview of imaging modalities currently used to assess microsphere biodistribution after liver radioembolization is presented. Secondly, the paper focuses on 90Y-PET dosimetry. A benchmark between a number of dosimetric approaches for accurate dosimetry after liver radioembolization with 90Y-PET dosimetry is presented.
| Item Type: | Article |
|---|---|
| Subjects: | 500 Scienze naturali e Matematica > 530 Fisica |
| Depositing User: | Marina Spanti |
| Date Deposited: | 17 Nov 2020 09:36 |
| Last Modified: | 17 Nov 2020 09:36 |
| URI: | http://eprints.bice.rm.cnr.it/id/eprint/19896 |
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