Salmonella infection as a trigger for Polyarteritis Nodosa

Tavares, Pedro and Alves, Patricia and Grácio, Rita and Costa, Paula and Falcão, Carla and Santos, Catarina and Amado, Filipa (2020) Salmonella infection as a trigger for Polyarteritis Nodosa. European Journal of Case Reports in Internal Medicine, 7 (3). ISSN 2284-2594

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Polyarteritis nodosa is a systemic necrotizing vasculitis that typically affects medium-sized muscular arteries, with occasional involvement of small muscular arteries. Most cases of polyarteritis nodosa are idiopathic but multiple infectious agents have been associated with this disease. We present a clinical case of a 72-year-old male with fever, diarrhoea and haemodynamic instability, diagnosed with a bacterial infection caused by Salmonella Typhi. One week after clinical resolution of the infection, the patient developed purpuric lesions with ulcers, pustules and necrotic areas accompanied by testicular pain and weight loss of 5 kg over the previous 15 days. A skin biopsy was performed and it revealed typical histologic signs of polyarteritis nodosa. The aetiologic association between bacteria of the genus Salmonella and polyarteritis nodosa has been previously described in the scientific literature but seldom meeting classification criteria and with histologic confirmation.

Item Type: Article
Uncontrolled Keywords: Polyarteritis nodosa, Salmonella, Salmonella Tiphy, vasculitis
Subjects: 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale)
Depositing User: Chiara D'Arpa
Date Deposited: 19 Nov 2020 10:12
Last Modified: 19 Nov 2020 10:12

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