Pinheiro, Guiomar and Costa, Ana Rita and Campar, Ana and Mendonça, Teresa (2020) Effectiveness of Tocilizumab in the Treatment of Fasciitis with Eosinophilia: Two Case Reports. European Journal of Case Reports in Internal Medicine, 7 (4). ISSN 2284-2594
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Abstract
Fasciitis with eosinophilia (FE) is a rare connective tissue disease. Due to its rarity, large-scale studies are lacking, which makes its treatment challenging. Systemic corticosteroids (SCSs) are the cornerstone of treatment; however, additional immunosuppressive drugs (ISDs) are frequently necessary (usually methotrexate). We report 2 patients, for whom an SCS and methotrexate were not a viable long-term option. In the first case, we were unable to taper the SCS dose without symptom relapse, the patient showed only a partial response to methotrexate and presented side effects. The second case never fully responded to the SCS and methotrexate and demonstrated serious SCS adverse effects. Both patients were started on tocilizumab with extremely favourable results, making this drug a potential therapeutic weapon for these patients.
| Item Type: | Article |
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| Uncontrolled Keywords: | Eosinophilic fasciitis, Shulman's disease, tolicizumab |
| Subjects: | 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) |
| Depositing User: | Chiara D'Arpa |
| Date Deposited: | 19 Nov 2020 10:17 |
| Last Modified: | 19 Nov 2020 10:17 |
| URI: | http://eprints.bice.rm.cnr.it/id/eprint/19957 |
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