Gatta, E. (2018) GABAA receptor modulation by the Antisecretory Factor on cerebellar granule cells. Il nuovo cimento C, 41 (3). pp. 1-8. ISSN 1826-9885
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Abstract
The Antisecretory Factor (AF, Mw 41kD) is an endogenous protein, found in all mammalian tissues. AF acts in vivo by counteracting intestinal hypersecretion and various forms of inflammations. The detailed in vitro AF action on the cellular level is unknown. Using an in vitro neuronal model (granular cells from rat small brain) we studied AF action on ionotropic GABAA receptors. A facilitatory activity, due to increased GABAA receptors expression, was demonstrated on the neuronal plasma membrane in response to AF influence. This effect may result in inhibition of intestinal secretomotor cells.
| Item Type: | Article |
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| Subjects: | 500 Scienze naturali e Matematica > 530 Fisica |
| Depositing User: | Marina Spanti |
| Date Deposited: | 18 Nov 2020 08:58 |
| Last Modified: | 18 Nov 2020 08:58 |
| URI: | http://eprints.bice.rm.cnr.it/id/eprint/20244 |
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