Minafra, Luigi and Cammarata, Francesco P. and Torrisi, Filippo and Forte, Giusi I. and Bravatà, Valentina (2018) Preliminary study of novel SRC tyrosine kinase inhibitor and proton therapy combined effect on glioblastoma multiforme cell line: In vitro evaluation of target therapy for the enhancement of protons effectiveness. Il nuovo cimento C, 41 (6). pp. 1-5. ISSN 1826-9885
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Abstract
The aim of this work was to evaluate proton therapy effectiveness in combination with a molecule SRC protein inhibitor for glioblastoma multiforme treatment. The role of this novel compound, Si306, is to interfere with glioblastoma carcinogenesis and progression, creating a radiosensitivity condition. The experiments were performed on U87 human glioblastoma multiforme cell line. Molecule concentrations of 10 μM and 20μM were tested in combination with proton irradiation doses of 2, 4, 10 and 21Gy. Cell survival evaluation was performed by clonogenic assay. The results showed that Si306 increases the efficacy of proton therapy reducing the surviving cells fraction significantly compared to treatment with protons only. These studies will support the preclinical phase realization, in order to evaluate proton therapy effects and molecularly targeted drug combined treatments.
| Item Type: | Article |
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| Subjects: | 500 Scienze naturali e Matematica > 530 Fisica |
| Depositing User: | Marina Spanti |
| Date Deposited: | 27 Nov 2020 09:35 |
| Last Modified: | 27 Nov 2020 09:35 |
| URI: | http://eprints.bice.rm.cnr.it/id/eprint/20338 |
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