Carante, M. P. (2018) An interface between the FLUKA transport code and the BIANCA biophysical model to predict the biological effectiveness of hadrontherapy beams. Il nuovo cimento C, 41 (6). pp. 1-8. ISSN 1826-9885
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Abstract
In the context of cell death induced by ionizing radiation, the BIANCA biophysical model was used to produce tables of biological effectiveness, in terms of α and β parameters typical of the linear quadratic model for cell survival curves; the tables were produced for irradiation by protons, helium ions and carbon ions over a wide energy range and for two cell lines of different radiosensitivity. By using these values, the predictions of BIANCA were compared with experimental data of RBE, and good agreement was found. After this validation step, the FLUKA radiation transport code, which can produce physical dose profiles for typical hadrontherapy beams, could read the α and β tables; thanks to such an interface between FLUKA and BIANCA, probabilities of cell death were predicted along depth-dose profiles. An example of a carbon spread out Bragg peak is shown, highlighting the differences in the biological response of different cell lines and the possible importance of using more than one cell line in the context of treatment plan optimization.
| Item Type: | Article |
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| Subjects: | 500 Scienze naturali e Matematica > 530 Fisica |
| Depositing User: | Marina Spanti |
| Date Deposited: | 27 Nov 2020 09:38 |
| Last Modified: | 27 Nov 2020 09:38 |
| URI: | http://eprints.bice.rm.cnr.it/id/eprint/20347 |
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