Garibaldi, F. and Bettinardi, V. and Brembilla, G. and Briganti, A. and Cisbani, E. (2020) US/TOF-PET endorectal probe compatible with MR, for diagnosis and staging of the prostate cancer. Il nuovo cimento C, 43 (1). pp. 1-10. ISSN 1826-9885
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Abstract
Prostate Cancer (PCa) is one of the most prevalent cancers worldwide. Early and accurate diagnosis of PCa is crucial for effective and successful treatment. Our project aims at developing a unique, highly performing flexible geometry multi-modality imaging system for diagnosis and staging of PCa. The imager will have the form of an endorectal probe combining high-resolution (0.1 mm) ultrasound (US) with a very high-resolution Positron Emission Tomography (PET) probe (1 mm spatial resolution) with exceptional Time-of-Flight (TOF) capability (100 ps FWHM targeted) compatible with Magnetic Resonance Imaging (MRI), in coincidence with a set of external PET panels. While standard multiparametric MRI (mpMR) has drawbacks, diagnosis will be improved significantly by the introduction of PSPMA-PET as well as the simultaneous PET/MR imaging. The system will be capable of morphological visualization instantly and continuously combined with biological and metabolic activity, offering crucial improvement with respect to standard systems (detection of ∼ 2 mm lesions vs. ∼ 6 mm lesions) in spatial resolution, efficiency, signal-to-noise ratio (SNR), scanning time and/or lowering injected dose.
| Item Type: | Article |
|---|---|
| Subjects: | 500 Scienze naturali e Matematica > 530 Fisica |
| Depositing User: | Marina Spanti |
| Date Deposited: | 29 Jan 2021 15:20 |
| Last Modified: | 29 Jan 2021 15:20 |
| URI: | http://eprints.bice.rm.cnr.it/id/eprint/20717 |
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