Peña-Muñoz, Felipe and Parras, Ernesto and Compan, Olga and Gutiérrez, Nora and Martin, Celestino and González-Porras, José Ramón and Bastida, Jose María (2020) Acquired Haemophilia A in Association with Influenza A and Urinary Tract Infection. European Journal of Case Reports in Internal Medicine, 7 (9). pp. 1-4. ISSN ISSN: 2284-2594
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Abstract
Acquired haemophilia A (AHA) is a rare autoimmune disorder caused by an autoantibody against any circulating coagulation factor, especially factor VIII (FVIII). The lack of awareness of this condition suggests that diagnosis is a challenge and usually delayed, which leads to suboptimal treatment. Consequently, early diagnosis is mandatory to prevent potentially life-threatening bleeding complications. We present the case of an 85-year-old woman admitted to hospital with symptoms of respiratory infection who 12 hours later developed haematuria which required transfusion. Laboratory assays showed an isolated prolonged aPTT, a moderately reduced FVIII and a high inhibitor titre. Influenza A and Escherichia coli were also identified. Antivirals, antibiotics, immunosuppressive drugs and haemostatic agents were started. Two weeks later, the inhibitor was not detected, and bleeding and symptoms of infection had resolved. Immunosuppressive drugs were stopped on day 45 and there has been no recurrence since then. To date, no FVIII inhibitors have been reported in concomitant infection with influenza A and urinary E. coli. The identification of conditions potentially associated with AHA is essential to achieve complete remission.
| Item Type: | Article |
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| Uncontrolled Keywords: | Acquired haemophilia, bleeding disorders, influenza, infectious diseases |
| Subjects: | 600 Tecnologia - Scienze applicate 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) |
| Depositing User: | Marina Spanti |
| Date Deposited: | 15 Dec 2021 12:21 |
| Last Modified: | 15 Dec 2021 12:21 |
| URI: | http://eprints.bice.rm.cnr.it/id/eprint/20983 |
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