Kim-Jun Teh, Kevin and Bingfeng Chuah, Matthew and Tay, Shu-Wen and Yuan-Ling Lim, Amanda and Joo-Ching Khoo, Joan (2020) Severe Symptomatic Hypophosphataemia as a Complication of Parenteral Iron Replacement. European Journal of Case Reports in Internal Medicine, 7 (11). pp. 1-2. ISSN ISSN: 2284-2594
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Abstract
Parental iron replacement is given to patients with severe iron deficiency or intolerance to oral iron. Hypophosphataemia has been reported to occur as a complication of parental iron replacement, and is postulated to be related to the carbohydrate moieties used in the parenteral preparations. Hypophosphataemia is under-diagnosed as symptoms such as fatigue, muscle weakness and poor effort tolerance mimic anaemia. Severe hypophosphataemia (<0.32 mmol/l) can result in significant complications such as confusion, rhabdomyolysis and arrhythmias. We report a patient with recurrent admissions for non-specific symptoms attributed to iron deficiency anaemia who received multiple doses of parenteral ferric carboxymaltose (FCM). He was found to have severe hypophosphataemia, with further evaluation showing increased renal phosphate wasting and elevated serum levels of fibroblast-growth-factor 23 (FGF23). FCM was stopped and he was given high-dose oral iron supplementation, with no further episodes of hypophosphataemia.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Hypophosphataemia, parenteral iron replacement, FGF23-mediated renal phosphate wasting |
| Subjects: | 600 Tecnologia - Scienze applicate 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) |
| Depositing User: | Marina Spanti |
| Date Deposited: | 15 Dec 2021 14:11 |
| Last Modified: | 15 Dec 2021 14:11 |
| URI: | http://eprints.bice.rm.cnr.it/id/eprint/21044 |
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