Akkad, Neha and Jiang, Yang and Shin, Daniel (2020) Leucocytosis and Stroke in a Lung Cancer Patient. European Journal of Case Reports in Internal Medicine, 7 (11). pp. 1-3. ISSN ISSN: 2284-2594
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Abstract
Significant leucocytosis in the setting of an underlying malignancy may be attributed to several causes and is not uncommon; however, extreme leucocytosis (>50×109 cells/l) and hypereosinophilia is less common and may represent a paraneoplastic syndrome. The underlying mechanism is thought to be bone marrow stimulation by tumour-produced cytokines, most notably interleukin-5 (IL-5) and granulocyte-macrophage colony-stimulating factor (GM-CSF). This paraneoplastic syndrome is likely reflective of extensive disease and dissemination, and options for treatment are limited but include tumour resection, corticosteroids and hydroxyurea. In this report, we discuss an unusual case of known stage III lung adenocarcinoma presenting with an ischaemic stroke and extreme leucocytosis and hypereosinophilia.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Haematology/oncology, non-small-cell lung cancer, leucocytosis, eosinophilia |
| Subjects: | 600 Tecnologia - Scienze applicate 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) |
| Depositing User: | Marina Spanti |
| Date Deposited: | 15 Dec 2021 14:12 |
| Last Modified: | 15 Dec 2021 14:12 |
| URI: | http://eprints.bice.rm.cnr.it/id/eprint/21046 |
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