An Unexpected Favourable Evolution of Advanced Stage Cirrhosis

Rabadão, Tiago and Naia, Leonor and Teixeira, Mariana and Aveiro, Marcelo and Ferreira, Filipa and Eulálio, Margarida and Calretas, Suzana (2020) An Unexpected Favourable Evolution of Advanced Stage Cirrhosis. European Journal of Case Reports in Internal Medicine, 7 (12). pp. 1-4. ISSN ISSN: 2284-2594

2122-Article Text-18759-1-10-20201126.pdf - Published Version

Download (627kB) | Preview
Official URL:


The elimination of the aetiological factors causing liver injury is an important cornerstone in preventing progression and increasing survival in patients with cirrhosis. The authors present the case of a 63-year-old woman with a history of long-term alcohol abuse and consequent liver cirrhosis. Over the years, the patient presented progressive deterioration with severe malnutrition and had multiple hospital admissions due to decompensated cirrhosis, including refractory ascites, variceal bleeding and an extensive portal vein thrombosis (PVT). Anticoagulant therapy was not initiated due to a high risk of variceal bleeding. She eventually became abstinent, but PVT precluded a liver transplant. Over the following 10 years, her performance status gradually improved, with no new decompensation episodes and liver function normalization, although refractory ascites persisted. Abdominal CT showed spontaneous recanalization of the portal vein and a transjugular intrahepatic portosystemic shunt (TIPS) procedure was performed with gradual improvement of ascites. In this atypical case, an unexpected favourable evolution of advanced stage cirrhosis was observed with long-term improvement in clinical status and liver function, resulting in an estimated 10-year cumulative mortality rate of 99.98% and highlighting the importance of abstinence. Unexpectedly, spontaneous complete repermeabilization of the PVT was also observed, despite its extent and the absence of anticoagulation therapy.

Item Type: Article
Uncontrolled Keywords: Decompensated cirrhosis, alcohol abstinence, portal vein thrombosis, refractory ascites, transjugular intrahepatic portosystemic shunt (TIPS)
Subjects: 600 Tecnologia - Scienze applicate
600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici)
600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale)
Depositing User: Marina Spanti
Date Deposited: 15 Dec 2021 14:37
Last Modified: 15 Dec 2021 14:37

Actions (login required)

View Item View Item