Awidi, Muhammad and Jain, Meenu and Baur, Russell (2021) Transplant-associated Thrombotic Microangiopathy Treated with Eculizumab and Romiplostim. European Journal of Case Reports in Internal Medicine, 8 (2). pp. 1-3. ISSN ISSN: 2284-2594
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Abstract
Transplant-associated thrombotic microangiopathy (TA-TMA) can occur after solid organ transplantation. It results in thrombocytopenia, haemolytic anaemia and microvascular occlusion. TA-TMA is not fully understood and treatment has not been clearly established. However, there is increasing evidence to suggest an immune-complement mediated component to its development. Eculizumab is a monoclonal antibody that inhibits the cleavage of C5 into pro-inflammatory, prothrombotic terminal complement elements and has been utilized in the treatment of atypical haemolytic uremic syndrome. We report a case of TA-TMA successfully treated with eculizumab and romiplostim. This case adds to the evidence that TA-TMA is triggered by complement dysregulation and suggests possible interventions for refractory cases.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Eculizumab, romiplostim, transplant thrombotic microangiopathy |
| Subjects: | 600 Tecnologia - Scienze applicate 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) |
| Depositing User: | Marina Spanti |
| Date Deposited: | 20 Dec 2021 15:24 |
| Last Modified: | 20 Dec 2021 15:24 |
| URI: | http://eprints.bice.rm.cnr.it/id/eprint/21184 |
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