Gonakoti, Sriram and Parra-Rodriguez, Luis (2021) Should CD4 Levels be Monitored in a Patient on Temozolomide? European Journal of Case Reports in Internal Medicine, 8 (3). pp. 1-4. ISSN ISSN: 2284-2594
|
Text
2276-Article Text-21171-1-10-20210310.pdf - Published Version Download (259kB) | Preview |
Abstract
Introduction: Temozolomide is an alkylating agent, indicated in the treatment of refractory anaplastic astrocytoma and newly diagnosed glioblastoma. We describe a case of Salmonella typhimurium bacteraemia associated with septic arthritis in the setting of concurrent temozolomide use. Case: A 67-year-old woman presented with acute onset of bilateral knee pain and swelling. She had a medical history of glioblastoma multiforme treated with temozolomide. Synovial fluid analysis and blood cultures revealed S. typhimurium, confirming a diagnosis of S. typhimurium bacteraemia associated with septic arthritis. Conclusion: We conclude that chemotherapy with temozolomide and corticosteroid use will increase an individual’s susceptibility to a wide variety of opportunistic infections akin to HIV-associated acquired immunodeficiency syndrome (AIDS). Furthermore, we hypothesize a possible benefit of monitoring CD4 levels and prophylaxis against opportunistic infections (based on the CD4 levels) in individuals receiving temozolomide-based chemotherapy, similar to HIV-AIDS.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Temozolomide, non-typhoidal salmonellae, septic arthritis |
| Subjects: | 600 Tecnologia - Scienze applicate 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) |
| Depositing User: | Marina Spanti |
| Date Deposited: | 21 Dec 2021 14:51 |
| Last Modified: | 21 Dec 2021 14:51 |
| URI: | http://eprints.bice.rm.cnr.it/id/eprint/21206 |
Actions (login required)
 |
View Item |
