Rodrigues Cernadas, Eduardo and Dionisio, Catarina and Estevão, Dália and Vicente, Leopoldina (2021) Reversible Neurological Adverse Reaction to Apixaban. European Journal of Case Reports in Internal Medicine, 8 (4). pp. 1-3. ISSN ISSN: 2284-2594
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Abstract
Prescriptions for the novel oral anticoagulant factor Xa inhibitors (rivaroxaban, apixaban, edoxaban) have equalled or exceeded those for vitamin K antagonists in many clinical settings requiring chronic anticoagulation, and those of injectable heparins for deep vein thrombosis prophylaxis. The authors report the case of an 80-year-old woman followed by her cardiologist for permanent atrial fibrillation who was prescribed apixaban. Within a few days the patient developed neurological symptoms of imbalance and non-vertiginous dizziness, headache, confusion/disorientation and asthenia. Her symptoms began to resolve after the drug was stopped, with return to baseline function within 72 h. The plasma concentration of apixaban was 4 times higher than the laboratory upper limit of normal. Symptoms did not recur when the patient was switched to rivaroxaban therapy.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Apixaban, neurological symptoms, adverse drug reaction |
| Subjects: | 600 Tecnologia - Scienze applicate 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) |
| Depositing User: | Marina Spanti |
| Date Deposited: | 21 Dec 2021 15:04 |
| Last Modified: | 21 Dec 2021 15:04 |
| URI: | http://eprints.bice.rm.cnr.it/id/eprint/21225 |
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