Tailoring superparamagnetic nanoparticles for entrapment into red blood cells

Slavu, L. M. and Di Corato, R. and Antonelli, A. and Scarpa, E. S. and Magnani, M. and Rinaldi, R. (2021) Tailoring superparamagnetic nanoparticles for entrapment into red blood cells. Il nuovo cimento C, 44 (4-5). pp. 1-4. ISSN 1826-9885

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The aim of the work here described is the synthesis of magnetic nanoparticles (MNPs) for the inclusion into human Red Blood Cells (RBCs) and as potential contrast agent for magnetic resonance imaging (MRI). Synthesis, characterization and preliminary in vitro tests are the main topics. Superparamagnetic iron oxide nanoparticles and manganese/zinc ferrite nanoparticles have been synthesized, by using wet-chemistry techniques such as co-precipitation and thermal decomposition methods. For biomedical application, a suitable surface coating must be grafted to MNPs surface, to preserve the colloidal stability even in physiological condition. Therefore, a biomimetic coating based on non-modified dextran was grafted to MNPs for ensuring optimal stability and low toxicity for the inclusion in living RBCs.

Item Type: Article
Subjects: 500 Scienze naturali e Matematica > 530 Fisica
Depositing User: Marina Spanti
Date Deposited: 20 Sep 2021 09:56
Last Modified: 20 Sep 2021 09:56
URI: http://eprints.bice.rm.cnr.it/id/eprint/21372

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