Zhao, Yi and Nozdrin, Mikhail and Dalla Pria, Alessia and Bracchi, Margherita (2021) Nannizziopsis Immune Reconstitution Inflammatory Syndrome in a Patient with HIV: First Reported Case. European Journal of Case Reports in Internal Medicine, 8 (11). pp. 1-4. ISSN 2284-2594
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Abstract
We describe the case of a 35-year-old HIV-positive male of African origin diagnosed with neurotoxoplasmosis and a Nannizziopsis spp. cavitating pulmonary lesion unmasking immune reconstitution inflammatory syndrome (IRIS).The patient presented with headache, left hemiparesis and confusion. MRI of the brain showed two space-occupying lesions in the right basal ganglia and left parietal lobe typical for neurotoxoplasmosis. The patient tested positive for HIV and had advanced CD4 lymphopenia. After commencement of antiretroviral treatment, a CT scan of the chest showed a cavitating lesion in the right upper lobe. The diagnosis of Nannizziopsis spp. fungal infection was confirmed by DNA sequencing on a bronchial wash sample. The patient achieved complete recovery with antiretroviral therapy, standard neurotoxoplasmosis treatment and antifungal treatment with voriconazole for 12 weeks.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HIV, immune reconstitution inflammatory syndrome, IRIS, Nannizziopsis |
| Subjects: | 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) |
| Depositing User: | Marina Spanti |
| Date Deposited: | 21 Feb 2022 12:53 |
| Last Modified: | 21 Feb 2022 12:53 |
| URI: | http://eprints.bice.rm.cnr.it/id/eprint/21739 |
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