Ceftriaxone-induced Encephalopathy: A Pharmacokinetic Approach

Jadot, Laurent and Judong, Aurelie and Canivet, Jean-Luc and Lorenzo-Villalba, Noel and Damas, Pierre (2021) Ceftriaxone-induced Encephalopathy: A Pharmacokinetic Approach. European Journal of Case Reports in Internal Medicine, 8 (11). pp. 1-4. ISSN 2284-2594

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We report a case of ceftriaxone-induced encephalopathy correlated with a high concentration of the drug in cerebrospinal fluid (CSF). Cephalosporin neurotoxicity is increasingly reported, especially in association with fourth-generation cephalosporins. The factors influencing CSF concentration are plasma concentration, liposolubility, ionization, molecular weight, protein binding and efflux. In our patient, high levels of ceftriaxone (27.9 mg/l) were found in CSF. β-Lactam-associated neurotoxicity is mainly due to similarities between GABA and the β-lactam ring. Because of differences in CSF/plasma ratios and blood–brain barrier efflux among patients, plasma drug monitoring cannot be used to estimate CSF concentration. As far as we know, this is the first reported case of ceftriaxone-induced encephalopathy associated with a high CSF concentration.

Item Type: Article
Uncontrolled Keywords: Encephalopathy, ceftriaxone, cerebrospinal fluid (CSF) concentration
Subjects: 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici)
Depositing User: Marina Spanti
Date Deposited: 21 Feb 2022 12:58
Last Modified: 21 Feb 2022 12:58
URI: http://eprints.bice.rm.cnr.it/id/eprint/21751

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