Ud Din, Mohammad Ammad and Liaqat, Hania and Osama, Muhammad (2021) MPL-Positive Essential Thrombocytosis Presenting as Budd-Chiari Syndrome in a Middle-Aged Woman with an Initially Normal Platelet Count. European Journal of Case Reports in Internal Medicine, 8 (12). pp. 1-3. ISSN 2284-2594
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Abstract
Budd-Chiari syndrome (BCS) results from an occlusion of the hepatic venous flow which in turn leads to portal hypertension causing ascites and other signs of liver dysfunction. Here, we present the case of a 43-year-old woman with recurrent ascites who was found to have BCS secondary to an inferior vena cava thrombosis extending into the hepatic veins. Although she had a normal platelet count on admission, additional laboratory investigations revealed an MPL mutation. She was discharged on anticoagulation with apixaban and later found to have thrombocytosis on repeat blood work, confirming the diagnosis of essential thrombocytosis, following which she was started on myelosuppressive therapy with hydroxyurea.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Veno-occlusive disease, myeloproliferative disorders, Budd-Chiari syndrome, essential thrombocytosis, malignant hematology |
| Subjects: | 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) |
| Depositing User: | Marina Spanti |
| Date Deposited: | 15 Mar 2022 16:46 |
| Last Modified: | 15 Mar 2022 16:46 |
| URI: | http://eprints.bice.rm.cnr.it/id/eprint/21765 |
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