Brero, F. and Calzolari, P. and Albino, M. and Antoccia, A. (2023) Iron oxide nanoparticles as agents for combined therapy and magnetic resonance imaging. Il nuovo cimento C, 46 (4). pp. 1-4. ISSN 1826-9885
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Abstract
Multifunctional iron-oxide based nanoparticles for magnetic fluid hyperthermia (MFH-therapy) and magnetic resonance imaging (MRI-diagnostics) have been investigated for their morpho-dimensional characteristics and relaxometric properties. The nanoparticles were constituted of a spherical Fe3O4 core with diameter d =19.2±3.6 nm, coated with meso-2,3-dimercaptosuccinic acid (DMSA). The 1H NMRresults showed a longitudinal r1 relaxivity curve typical of high-anisotropy materials and a transverse relaxivity that, at clinical field μ0H =1.5tesla,was∼3 times higher than the one of commercial MRI contrast agents. The system displayed aSAR∼110±30 W/gFe3O4 , i.e., high enough to allow for a successful combination of MFH-assisted-hyperthermia and hadron therapy on pancreatic tumor cells.
| Item Type: | Article |
|---|---|
| Subjects: | 500 Scienze naturali e Matematica > 530 Fisica |
| Depositing User: | Marina Spanti |
| Date Deposited: | 15 Feb 2024 10:40 |
| Last Modified: | 15 Feb 2024 10:40 |
| URI: | http://eprints.bice.rm.cnr.it/id/eprint/22700 |
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