Resting state activity in patients with disorders of consciousness

Soddu, Andrea and Vanhaudenhuyse, Audrey and Demertzi, Athena and Bruno, Marie-Aurélie and Tshibanda, Luaba and Di, Haibo and Boly, Mélanie and Papa, Michele and Laureys, Steven and Noirhomme, Quentin (2011) Resting state activity in patients with disorders of consciousness. Functional Neurology; New Trends in Interventional Neurosciences. , 26 (1). pp. 37-43. ISSN 0393-5264

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Recent advances in the study of spontaneous brain activity have demonstrated activity patterns that emerge with no task performance or sensory stimulation; these discoveries hold promise for the study of higher-order associative network functionality. Additionally, such advances are argued to be relevant in pathological states, such as disorders of consciousness (DOC), i.e., coma, vegetative and minimally conscious states. Recent studies on resting state activity in DOC, measured with functional magnetic resonance imaging (fMRI) techniques, show that functional connectivity is disrupted in the task-negative or the default mode network. However, the two main approaches employed in the analysis of resting state functional connectivity data (i.e., hypothesis-driven seed-voxel and data-driven independent component analysis) present multiple methodological difficulties, especially in non-collaborative DOC patients. Improvements in motion artifact removal and spatial normalization are needed before fMRI resting state data can be used as proper biomarkers in severe brain injury. However, we anticipate that such developments will boost clinical resting state fMRI studies, allowing for easy and fast acquisitions and ultimately improve the diagnosis and prognosis in the absence of DOC patients’ active collaboration in data acquisition.

Item Type: Article
Subjects: 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.8 Malattie del sistema nervoso e disturbi mentali (Classificare qui la Neuropsichiatria, la Neurologia)
Depositing User: Danilo Dezzi
Date Deposited: 03 Oct 2011 12:26
Last Modified: 03 Oct 2011 12:26

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