The principal strata effect for post-randomization selection bias : application to a prostate cancer prevention trial

Chiba, Yasutaka and Banba, Ikuko and Azuma, Kenichi (2010) The principal strata effect for post-randomization selection bias : application to a prostate cancer prevention trial. Biomedical statistics and clinical epidemiology , 4 (1). pp. 47-53. ISSN 1973-2430

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Abstract

Objectives. An approach that deals with post-randomization selection bias is to consider the principal strata effect (PSE). In this paper, the concept of the PSE is introduced, aimed at researchers. The practicality of a sensitivity analysis method that has recently been developed is also investigated. Although a formula for the method had been presented previously, its practicability with real data has not been discussed for general cases. Methods. The PSE is introduced using a simple hypothetical example. Whether the sensitivity analysis method is practical is examined by applying the process to an actual prostate cancer prevention trial. Results. The sensitivity analysis could be readily conducted, and the results could be displayed graphically using Monte Carlo sensitivity analysis. Conclusions. The sensitivity analysis requires prior distributions of sensitivity parameters. Thus, it will be useful for diseasespecific experts, who have sufficient clinical knowledge, and statisticians, who can conduct the sensitivity analysis, to work closely together for the sensitivity analysis.

Item Type:	Article
Uncontrolled Keywords:	bounds, causal inference, Monte Carlo sensitivity analysis, potential outcome, principal stratification, randomized trial
Subjects:	500 Scienze naturali e Matematica > 570 Scienze della vita; Biologia > 570.15195 Statistica in Biologia (Classificare qui la Biometria, la Biostatistica) 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 610.7 Medicina - Educazione e Insegnamento; Medicina - Ricerca > 610.72 Statistica medica 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.6 Malattie del sistema urogenitale, malattie del sistema urinario 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.9 Altre malattie (altri rami della Medicina) > 616.99 Tumori, malattie contagiose
Depositing User:	Emanuele Zinevrakis
Date Deposited:	07 Nov 2011 14:39
Last Modified:	07 Nov 2011 14:39
URI:	http://eprints.bice.rm.cnr.it/id/eprint/3502

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