Ataxia and the olivo-cerebellar module

Libster, Avraham M. and Lefler, Yaara and Yaron-Jakoubovitch, Anat and Yarom, Yosef (2010) Ataxia and the olivo-cerebellar module. Functional Neurology; New Trends in Interventional Neurosciences, 25 (3). pp. 129-133. ISSN 1971-3274

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Abstract

Ataxia is a neurological symptom characterized by abnormal movement, due to cerebellar malfunction. Although the cause of the malfunction varies, from mutations in calcium or potassium channels to progressive degeneration of cerebellar tissue, the neurological symptoms of cerebellar-related ataxia are similar. In this short review we present a model that portrays the olivo-cerebellar system as a generator of temporal patterns. We then use the model to explain how mutations in different ionic channels located in different parts of the cerebellar system can result in similar neurological symptoms

Item Type:	Article
Uncontrolled Keywords:	Deep cerebellar nuclei, inferior olive, oscillations, Purkinje cells
Subjects:	600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.8 Malattie del sistema nervoso e disturbi mentali (Classificare qui la Neuropsichiatria, la Neurologia)
Depositing User:	Danilo Dezzi
Date Deposited:	06 Jan 2012 15:22
Last Modified:	06 Jan 2012 15:22
URI:	http://eprints.bice.rm.cnr.it/id/eprint/3549

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