Ataxias and cerebellar dysfunction: involvement of synaptic plasticity deficits?

Rinaldo, Lorenzo and Hansel, Christian (2010) Ataxias and cerebellar dysfunction: involvement of synaptic plasticity deficits? Functional Neurology; New Trends in Interventional Neurosciences, 25 (3). pp. 135-139. ISSN 1971-3274

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Adaptive processes within cerebellar circuits, such as long-term depression and long-term potentiation at parallel fiber-Purkinje cell synapses, have long been seen as important to cerebellar motor learning, and yet little attention has been given to any possible significance of these processes for cerebellar dysfunction and disease. Several forms of ataxia are caused by mutations in genes encoding for ion channels located at key junctures in pathways that lead to the induction of synaptic plasticity, suggesting that there might be an association between deficits in plasticity and the ataxic phenotype. Herein we explore this possibility and examine the available evidence linking the two together, highlighting specifically the role of P/Q-type calcium channels and their downstream effector small-conductance calcium-sensitive (SK2) potassium channels in the regulation of synaptic gain and intrinsic excitability, and reviewing their connections to ataxia

Item Type: Article
Uncontrolled Keywords: Episodic ataxia type 2, long-term depression, long-term potentiation, P/Q-type voltage-gated calcium channel, Purkinje cell, SK2 channel.
Subjects: 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.8 Malattie del sistema nervoso e disturbi mentali (Classificare qui la Neuropsichiatria, la Neurologia)
Depositing User: Danilo Dezzi
Date Deposited: 08 Jan 2012 18:57
Last Modified: 08 Jan 2012 18:57

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