Night-time use of rotigotine in advanced Parkinson’s disease

Canesi, Margherita and Mariani, Claudio B. and Isaias, Ioannis U. and Pezzoli, Gianni (2010) Night-time use of rotigotine in advanced Parkinson’s disease. Functional Neurology; New Trends in Interventional Neurosciences, 25 (4). pp. 201-203. ISSN 1971-3274

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Abstract

Transdermal rotigotine was used in six patients with advanced Parkinson’s disease and sleep disorders (UPDRS part II item 12 score ≥2) receiving oral levodopa and diurnal apomorphine infusions. Transdermal rotigotine (2-4 mg/24h) was used at night for four months. Sleep disorders improved, the total Parkinson’s Disease Sleep Scale score falling by an average of 45%; significant improvements emerged in the items quality of sleep and difficulty in remaining asleep (p<0.05). No undesirable dopaminergic effects were reported. This preliminary open-label study suggests that transdermal rotigotine may be a well tolerated and effective treatment in patients with advanced Parkinson’s disease, reducing nocturnal disability and ameliorating sleep disorders without inducing undesirable dopaminergic effects

Item Type:	Article
Uncontrolled Keywords:	Parkinson’s disease, rotigotine, sleep disorders
Subjects:	600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.8 Malattie del sistema nervoso e disturbi mentali (Classificare qui la Neuropsichiatria, la Neurologia) 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.8 Malattie del sistema nervoso e disturbi mentali (Classificare qui la Neuropsichiatria, la Neurologia) > 616.83 Altre malattie organiche del sistema nervoso centrale (Include la corea ed i disturbi coreici ad eccezione della malattia di Huntington (in 616.851) (Classificare qui, in 616.83, le malattie dei gangli vasali, del midollo spinale) > 616.833 Malattia di Parkinson (Include il parkinsonismo post-encefalitico)
Depositing User:	Danilo Dezzi
Date Deposited:	01 Jun 2012 15:43
Last Modified:	07 Jun 2012 08:10
URI:	http://eprints.bice.rm.cnr.it/id/eprint/3582

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