Heart rate variability in facioscapulohumeral muscular dystrophy

Della Marca, Giacomo and Frusciante, Roberto and Scatena, Michele and Dittoni, Serena and Testani, Elisa and Vollono, Catello and Losurdo, Anna and Scarano, Emanuele and Colicchio, Salvatore and Farina, Benedetto and Gnoni, Valentina and Mazza, Salvatore and Tonali, Pietro Attilio and Ricci, Enzo (2010) Heart rate variability in facioscapulohumeral muscular dystrophy. Functional Neurology; New Trends in Interventional Neurosciences, 25 (4). pp. 211-216. ISSN 1971-3274

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Abstract

Facioscapulohumeral muscular dystrophy (FSHD) is the third most frequent form of muscular dystrophy. Heart rate variability (HRV) analysis is a means of evaluating the activity of the autonomic nervous system. The aim of this study was to evaluate HRV in FSHD patients. Fifty-five consecutive FSHD patients were enrolled (31 men, age 26-72 years). Muscular impairment was measured using a clinical severity scale (CSS). Patients were compared with a control group of 55 healthy subjects, matched for age and sex. HRV was analyzed in the time domain and in the frequency domain. Patients showed increased spectral power of the low-frequency band. Spectral power of the high-frequency band was inversely correlated with CSS score. FSHD is associated with a slight increase in sympathetic output and with a decrease in parasympathetic output. These modifications become more evident with the progression of the disease and could increase the risk of arrhythmias and other cardiovascular events

Item Type:	Article
Uncontrolled Keywords:	Arrhythmias, autonomic nervous system, ECG, facioscapulohumeral muscular dystrophy, heart rate variability
Subjects:	600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.7 Malattie del sistema muscoloscheletrico 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.8 Malattie del sistema nervoso e disturbi mentali (Classificare qui la Neuropsichiatria, la Neurologia)
Depositing User:	Danilo Dezzi
Date Deposited:	04 Jun 2012 07:22
Last Modified:	04 Jun 2012 07:22
URI:	http://eprints.bice.rm.cnr.it/id/eprint/3585

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