The severity of chronic cerebrospinal venous insufficiency in patients with multiple sclerosis is related to altered cerebrospinal fluid dynamics

Zamboni, Paolo and Menegatti, Erica and Weinstock-Guttman, Bianca and Schirda, Claudiu V. and Cox, Jennifer L. and Malagoni, Anna M. and Hojnacki, David and Kennedy, Cheryl and Carl, Ellen and Dwyer, Michael G. and Bergsland, Niels and Galeotti, Roberto and Hussein, Sara and Bartolomei, Ilaria and Salvi, Fabrizio and Zivadinov, Robert (2009) The severity of chronic cerebrospinal venous insufficiency in patients with multiple sclerosis is related to altered cerebrospinal fluid dynamics. Functional Neurology; New Trends in Interventional Neurosciences, 24 (3). pp. 133-138. ISSN 1971-3274

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Abstract

Chronic cerebrospinal venous insufficiency (CCSVI) is a vascular picture that shows a strong association with multiple sclerosis (MS). The aim of this study was to investigate the relationship between a Doppler cerebral venous hemodynamic insufficiency severity score (VHISS) and cerebrospinal fluid (CSF) flow dynamics in 16 patients presenting with CCSVI and relapsing-remitting MS (CCSVI-MS) and in eight healthy controls (HCs). The two groups (patients and controls) were evaluated using validated echo-Doppler and advanced 3T-MRI CSF flow measures. Compared with the HCs, the CCSVI-MS patients showed a significantly lower net CSF flow (p=0.027) which was highly associated with the VHISS (r=0.8280, r2=0.6855; p=0.0001). This study demonstrates that venous outflow disturbances in the form of CCSVI significantly impact on CSF pathophysiology in patients with MS

Item Type:	Article
Uncontrolled Keywords:	Chronic cerebrospinal venous insufficiency, CCSVI, CSF, echo-Doppler, MRI, multiple sclerosis
Subjects:	600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.8 Malattie del sistema nervoso e disturbi mentali (Classificare qui la Neuropsichiatria, la Neurologia) > 616.8047548 Sistema Nervoso – Risonanza magnetica nucleare (Classificare qui: Neuroimaging, Neuroimaging funzionale, Cervello - Risonanza magnetica funzionale, Cervello - Risonanza magnetica per immagini) 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.8 Malattie del sistema nervoso e disturbi mentali (Classificare qui la Neuropsichiatria, la Neurologia) > 616.83 Altre malattie organiche del sistema nervoso centrale (Include la corea ed i disturbi coreici ad eccezione della malattia di Huntington (in 616.851) (Classificare qui, in 616.83, le malattie dei gangli vasali, del midollo spinale) 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.8 Malattie del sistema nervoso e disturbi mentali (Classificare qui la Neuropsichiatria, la Neurologia) > 616.83 Altre malattie organiche del sistema nervoso centrale (Include la corea ed i disturbi coreici ad eccezione della malattia di Huntington (in 616.851) (Classificare qui, in 616.83, le malattie dei gangli vasali, del midollo spinale) > 616.834 Sclerosi multipla
Depositing User:	Danilo Dezzi
Date Deposited:	09 Jul 2012 11:39
Last Modified:	09 Jul 2012 11:39
URI:	http://eprints.bice.rm.cnr.it/id/eprint/3623

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