Gait analysis and cerebral volumes in Downʼs Syndrome

Rigoldi, Chiara and Galli, Manuela and Condoluci, Claudia and Carducci, Filippo and Onorati, Paolo and Albertini, Giorgio (2009) Gait analysis and cerebral volumes in Downʼs Syndrome. Functional Neurology; New Trends in Interventional Neurosciences, 24 (3). pp. 147-152. ISSN 1971-3274

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Abstract

The aim of this study was to look for a relationship between cerebral volumes computed using a voxel-based morphometry algorithm and walking patterns in individuals with Downʼs syndrome (DS), in order to investigate the origin of the motor problems in these subjects with a view to developing appropriate rehabilitation programmes. Nine children with DS underwent a gait analysis (GA) protocol that used a 3D motion analysis system, force plates and a video system, and magnetic resonance imaging (MRI). Analysis of GA graphs allowed a series of parameters to be defined and computed in order to quantify gait patterns. By combining some of the parameters it was possible to obtain a 3D description of gait in terms of distance from normal values. Finally, the results of cerebral volume analysis were compared with the gait patterns found. A strong relationship emerged between cerebellar vermis volume reduction and quality of gait and also between grey matter volume reduction of some cerebral areas and asymmetrical gait. An evaluation of high-level motor deficits, reflected in a lack or partial lack of proximal functions, is important in order to define a correct rehabilitation programme

Item Type:	Article
Uncontrolled Keywords:	Cerebral volumes, Downʼs syndrome, gait analysis, optimised voxel-based morphometry
Subjects:	600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.8 Malattie del sistema nervoso e disturbi mentali (Classificare qui la Neuropsichiatria, la Neurologia) > 616.85 Malattie varie del sistema nervoso e disturbi mentali di diverso genere > 616.858 Disturbi della personalità, sessuali, dell’identità di genere, del controllo degli impulsi, fittizi, dello sviluppo, dell’apprendimento; comportamento violento, ritardo mentale > 616.8588 Ritardo mentale; disturbi dello sviluppo e dell’apprendimento (Classificare qui i disturbi mentali solitamente diagnosticati in primo luogo nell’infanzia, nell’adolescenza) > 616.858842 Sindrome di Down 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 618 Altri rami della medicina; Ginecologia e ostetricia, Pediatria, Geriatria > 618.9 Pediatria e Geriatria > 618.92 Pediatria (Malattie degli infanti e dei bambini fino alla pubertà) > 618.928 Malattie del sistema nervoso e disturbi mentali (Classificare qui la Neuropsichiatria infantile e dell’adolescenza) > 618.9285 Malattie varie del sistema nervoso e disturbi menatali vari > 618.92858 Disturbi della personalità, sessuali, dell’identità di genere, del controllo, degli impulsi, fittizi, dello sviluppo, dell’apprendimento; comportamento violento, ritardo mentale > 618.928588 Ritardo mentale; disturbi dello sviluppo e dell’apprendimento > 618.9285884 Ritardo mentale causato da disturbi genetici, altre anomalie congenite
Depositing User:	Danilo Dezzi
Date Deposited:	13 Jul 2012 12:27
Last Modified:	13 Jul 2012 12:27
URI:	http://eprints.bice.rm.cnr.it/id/eprint/3629

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