Combined effects of botulinum toxin and casting treatments on lower limb spasticity after stroke

Farina, Simona and Migliorini, Claudia and Gandolfi, Marialuisa and Bertolasi, Laura and Casarotto, Matteo and Manganotti, Paolo and Fiaschi, Antonio and Smania, Nicola (2008) Combined effects of botulinum toxin and casting treatments on lower limb spasticity after stroke. Functional Neurology; New Trends in Interventional Neurosciences, 23 (2). pp. 87-91. ISSN 1971-3274

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Abstract

Optimal treatment of spasticity requires a combination of pharmacotherapy and muscle lengthening. We evaluated 13 stroke patients with equinovarus foot randomized to treatment with either botulinum toxin A (BTA) injection plus ankle-foot casting (n=6) or BTA alone (n=7). The tibialis posterior and calf muscles (range of BTA injection: 190 to 320 U) were treated in each patient. Castings were worn at night for four months. Each patient was examined before, and at two and four months after BTA injection using the static and dynamic baropodometric tests, the Modified Ashworth Scale and the 10-meter walking test. At two months, therapeutic effects were observed in both groups. At four months, the study group showed further clinical improvement, while the control group returned to baseline performance. Thus, prolonged stretching of spastic muscles after BTA injection affords long-lasting therapeutic benefit, enhancing the effects of the toxin alone

Item Type:	Article
Uncontrolled Keywords:	Ankle-foot casting, botulinum toxin, lower limb spasticity
Subjects:	600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 615 Farmacologia e terapeutica > 615.8 Specifiche terapie e tipi di terapia 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.8 Malattie del sistema nervoso e disturbi mentali (Classificare qui la Neuropsichiatria, la Neurologia) > 616.81 Sistema nervoso - Malattie cerebrovascolari (Classificare qui l’Apoplessia cerebrale, l'Ischemia cerebrale, Ictus cerebrale) 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.8 Malattie del sistema nervoso e disturbi mentali (Classificare qui la Neuropsichiatria, la Neurologia) > 616.84 Manifestazioni delle malattie neurologiche (Classificare qui la patologia, la diagnosi, il trattamento dei sintomi)
Depositing User:	Danilo Dezzi
Date Deposited:	18 Jul 2012 11:59
Last Modified:	18 Jul 2012 11:59
URI:	http://eprints.bice.rm.cnr.it/id/eprint/3683

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