Complications in major depressive disorder therapy: a review of magnetic resonance spectroscopy studies

Caverzasi, Eduardo and Pichiecchio, Anna and Calligaro, Alessandro and Pasin, Moreno and Giugni, Elisabetta and Pasquini, Massimo and Biondi, Massimo and Barale, Francesco and Bastianello, Stefano (2008) Complications in major depressive disorder therapy: a review of magnetic resonance spectroscopy studies. Functional Neurology; New Trends in Interventional Neurosciences, 23 (3). pp. 129-132. ISSN 1971-3274

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Advanced magnetic resonance imaging techniques, such as proton magnetic resonance spectroscopy (H-MRS), have helped to further understanding of the pathophysiology of major depressive disorder (MDD) and to shed light on mechanisms underlying the therapeutic response. Potential complications of MDD therapy constitute an important area of research. Interruption of the absorption of serotonin reuptake inhibitors (SSRIs) is associated with discontinuation syndrome, while electroconvulsive therapy (ECT) can lead to transient and persistent anterograde amnesia. This paper reviews studies, since 1994, that have used H-MRS to evaluate adverse effects and complications of MDD treatment, either with ECT or SSRIs. Three articles have been published on adverse effects and complications of MDD treatment and H-MRS. Two focused on the ECT-induced memory deterioration and showed no sign of hippocampal atrophy in MDD patients with a residual memory deterioration after ECT, but a significant mean increase of the signal from Cho-containing compounds bilaterally, possibly due to an alteration of membrane turnover in the hippocampal region. The third paper showed that placebo-day Cho/Cr metabolite ratios were decreased in subjects with discontinuation syndrome, a finding that possibly reflects the dynamics of rostral anterior cingulate function. In spite of the limits deriving from the small number of papers published, our review demonstrated that H-MRS could be a useful instrument not only in evaluating therapy efficacy, but also for offering new insights into mechanisms underlying MDD treatments

Item Type: Article
Uncontrolled Keywords: Advanced MRI technique, major depression disorder, spectroscopy, therapy
Subjects: 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.8 Malattie del sistema nervoso e disturbi mentali (Classificare qui la Neuropsichiatria, la Neurologia) > 616.85 Malattie varie del sistema nervoso e disturbi mentali di diverso genere > 616.852 Nevrosi (Include i disturbi d’adattamento) > 616.8527 Disturbi depressivi (Include il Disturbo Affettivo Stagionale (DAS) (Classificare qui le opere d’insieme sulla depressione, sui disturbi dell’umore)
Depositing User: Danilo Dezzi
Date Deposited: 13 Jul 2012 08:29
Last Modified: 13 Jul 2012 08:29

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