Clinical implications of patent foramen ovale in migraine with aura

Marchione, Pasquale and Ghiotto, Natascia and Sances, Grazia and Guaschino, Elena and Bosone, Daniele and Nappi, Giuseppe and Giacomini, Patrizia (2008) Clinical implications of patent foramen ovale in migraine with aura. Functional Neurology; New Trends in Interventional Neurosciences, 23 (4). pp. 201-205. ISSN 1971-3274

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Abstract

The high incidence of patent foramen ovale (PFO) in migraine with aura (MWA) is well known. In this study we evaluated the relationship between PFO and aura features, and the relative impact of this association on stroke risk. We recruited patients with a diagnosis of MWA. PFO was assessed by contrast transcranial Doppler and confirmed by transoesophageal echocardiography. The 65 patients enrolled were divided into two groups on the basis of the clinical features of their aura: typical in 63.1% (Group 1) and atypical in 36.9% (Group 2). A statistically significant difference was found in PFO prevalence between the two groups (46.3% in Group 1 and 79.2% in Group 2; p=0.009). We did not observe any statistical difference between the two groups in the prevalence of classic stroke risk factors or in the profile of the thrombophilic markers. Our results underline the need to look for PFO particularly in subjects with atypical features of aura, but the underlying pathophysiology of the association is not clear

Item Type:	Article
Uncontrolled Keywords:	Migraine with aura, patent foramen ovale, prolonged aura, transcranial Doppler
Subjects:	600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.8 Malattie del sistema nervoso e disturbi mentali (Classificare qui la Neuropsichiatria, la Neurologia) 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.8 Malattie del sistema nervoso e disturbi mentali (Classificare qui la Neuropsichiatria, la Neurologia) > 616.8047548 Sistema Nervoso – Risonanza magnetica nucleare (Classificare qui: Neuroimaging, Neuroimaging funzionale, Cervello - Risonanza magnetica funzionale, Cervello - Risonanza magnetica per immagini)
Depositing User:	Danilo Dezzi
Date Deposited:	08 May 2012 10:36
Last Modified:	08 May 2012 10:36
URI:	http://eprints.bice.rm.cnr.it/id/eprint/3703

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