Slawek, Jaroslaw and Friedman, Andrzej and Potulska, Anna and Krystkowiak, Pierre and Gervais, Claire and Banach, Marta and Ochudlo, Stanislaw and Budrewicz, Slawomir and Reclawowicz, Daniel and Rynkowski, Michal and Opala, Grzegorz (2007) Factors affecting the health-related quality of life of patients with cervical dystonia and the impact of botulinum toxin type A injections. Functional Neurology, 22 (2). pp. 95-100. ISSN 1971-3274
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Abstract
The purpose of this study was to analyze the health-related quality of life (HRQL) of patients with cervical dystonia (CD) and the impact of botulinum toxin A (BTX-A) therapy in these patients. The authors recruited 101 patients with CD, all previously treated with BTX-A. Both before and 4 weeks after injection of BTX-A the patients were assessed using the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS), a Visual Analogue Scale for pain (VAS: 0-100%), the Short Form 36 health survey questionnaire (SF-36), and the Montgomery-Asberg Depression Rating Scale (MADRS). A control group of 84 healthy volunteers was also evaluated. The patients’ baseline SF-36 scores were worse in all the domains when compared with those of the controls. Depression was found in 47.5% of the patients. Improvements were noticed 4 weeks after the single BTX-A injections in all the SF-36 domains, and in the VAS, TWSTRS and MADRS scores. The TWSTRS results did not correlate with any of the SF-36 subscores. Stepwise backward regression analysis revealed depression as the main predictor of poor HRQL, as well as female sex, poor financial situation, and living alone. On contrary, longer treatment with BTX-A was associated with better scores. Cervical dystonia has a marked impact on HRQL and treatment with BTX-A injections has a beneficial effect, seen both in objective and in subjective measures. Depression in CD patients is a main predictor of worse HRQL
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Botulinum toxin type A, cervical dystonia, health-related quality of life. |
| Subjects: | 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.8 Malattie del sistema nervoso e disturbi mentali (Classificare qui la Neuropsichiatria, la Neurologia) |
| Depositing User: | Danilo Dezzi |
| Date Deposited: | 17 Feb 2012 08:19 |
| Last Modified: | 28 Jan 2016 16:29 |
| URI: | http://eprints.bice.rm.cnr.it/id/eprint/3719 |
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