Genes, proteases, cortical spreading depression and migraine: impact on pathophysiology and treatment

Moskowitz, Michael A. (2007) Genes, proteases, cortical spreading depression and migraine: impact on pathophysiology and treatment. Functional Neurology; New Trends in Interventional Neurosciences, 22 (3). pp. 133-136. ISSN 1971-3274

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Abstract

Migraine headaches have a complex pathophysiology; both vascular and neuronal mechanisms have been proposed. One possible scenario begins with a series of destabilising events within the brain that trigger cortical spreading depression (CSD). CSD can cause both migraine aura and trigeminal activation which, in turn, promotes neuropeptide release and triggers peripheral and central mechanisms that promote headache and autonomic activation. Susceptibility to CSD and to migraine is, in part, genetically determined. The best evidence to date comes from certain subtypes of migraine with aura in which point mutations in genes controlling translocation of calcium, sodium and potassium have been implicated. This review briefly summarises recent migraine research that supports CSD as an upstream driver of the migraine attack as well as an activator of the trigeminovascular system

Item Type:	Article
Uncontrolled Keywords:	Ion channel, migraine, neurogenic inflammation, pathophysiology, spreading depression, trigeminal nerve
Subjects:	600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.8 Malattie del sistema nervoso e disturbi mentali (Classificare qui la Neuropsichiatria, la Neurologia)
Depositing User:	Danilo Dezzi
Date Deposited:	15 Feb 2012 08:12
Last Modified:	15 Feb 2012 08:12
URI:	http://eprints.bice.rm.cnr.it/id/eprint/3728

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