Is there a role for nitric oxide activity in cervicogenic headache?

Inan, Nurten and Yilmaz, Gulsen and Surer, Hatice and Coskun, Ozlem and Ucler, Serap and Cavdar, Leyla and Inan, Levent E. (2007) Is there a role for nitric oxide activity in cervicogenic headache? Functional Neurology; New Trends in Interventional Neurosciences, 22 (3). pp. 155-157. ISSN 1971-3274

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Cervicogenic headache (CEH) is a unilateral headache that can be provoked by neck movement, awkward head positions or pressure on tender points in the neck. The mechanisms underlying the stimulation of pain in CEH are not clearly known. In this study, we measured serum nitrate and nitrite levels as an index of nitric oxide (NO) activity in 15 patients with CEH during headache and headache-free periods and in 15 healthy controls. Total nitrate+nitrite levels were found to be higher in CEH patients during headache periods than in healthy controls (20.7±3.8 µmol/l vs 14.4±3.6 µmol/l, p<0.001), but not in CEH patients during headache-free periods (16.1±2.2 µmol/l) compared with the controls (p>0.05). In the patients with CEH, serum total nitrate+nitrite levels were found to be higher during headache periods than during headache-free periods (p=0.001). It can thus be hypothesized that the changes observed are a cause of the attack rather than a consequence of the disease process.

Item Type: Article
Uncontrolled Keywords: Cervicogenic headache, nitrate, nitric oxide, nitrite
Subjects: 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.8 Malattie del sistema nervoso e disturbi mentali (Classificare qui la Neuropsichiatria, la Neurologia)
Depositing User: Danilo Dezzi
Date Deposited: 31 Jan 2012 09:00
Last Modified: 31 Jan 2012 09:00

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