Bone-defects healing by high-molecular hyaluronic acid: preliminary results

Baldini, Alberto and Zaffe, Davide and Nicolini, Gabriella (2010) Bone-defects healing by high-molecular hyaluronic acid: preliminary results. Annali di stomatologia, 1 (1). pp. 2-7. ISSN 1971-1441


Download (13MB)
Official URL:


Summary: Bone-defects healing by high-molecular hyaluronic acid: preliminary results. Aim: The aim of this study is to evaluate the capability of Hyaloss™ matrix (Fab – Fidia Advanced Biopolymers – Pd – Italy), a biomaterial based on hyaluronic acid, used as organic scaffold in bone repair in post-extractive defects. Materials and methods: 20 post-extractive sockets were selected, with similar size defects in the same patient and in the same hemiarch. Hyaluronic acid with high molecular weight (Hyaloss™ matrix, Fab – Pd – Italy) was mixed with autologous bone obtained using Safescraper ® curve (Meta – Re – Italy) to repair post-extractive sites. Safescraper® is a cutting edge system that allows to the collection of autologous bone without using traditional, incision-based collection techniques, which could cause discomfort to the patient. Results: Clinical and hystological evaluations were performed, four months after grafting, in the maxilla and in the mandible. From a clinical point of view Hyaloss™ matrix mixed with autologous bone and patient’s blood becomes a substance similar to gel, which is easy to insert in to the defect. From a hystological point of view, in the treated site there is the presence of an erosive activity, with accelerated angiogenetic and bone remodelling activities. Conclusions: The preliminary results show an acceleration of the bone deposit process and of its remodelling due to the presence of Hyaloss™ matrix, which, from a clinical point of view, improves the handling and application of the bone matrix inside the defects and, from a hystologic point of view makes it possible to obtain bone regeneration in less time when it is used with autologous bone.

Item Type: Article
Uncontrolled Keywords: Autologous bone, hyaluronic acid, bone, bone defect healing, bone graft
Subjects: 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 617 Rami vari della medicina; Chirurgia > 617.5 Medicina regionale; Chirurgia regionale
Depositing User: Chiara D'Arpa
Date Deposited: 03 Apr 2013 09:28
Last Modified: 15 May 2013 11:16

Actions (login required)

View Item View Item