Proteomic analysis for the study of amniotic fluid protein composition

Perluigi, Marzia and Di Domenico, Fabio and Cini, Chiara and Coccia, Raffaella and Giorlandino, Francesca Romana and Giorlandino, Maurizio and Cignini, Piero and Mesoraca, Alvaro and Giorlandino, Claudio (2009) Proteomic analysis for the study of amniotic fluid protein composition. Journal of prenatal medicine, 3 (3). pp. 39-41. ISSN 1971-3290

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Amniotic fluid (AF), routinely used for prenatal diagnosis, contains large amounts of proteins produced by the amnion epithelial cells, fetal tissues, fetal excretions and placental tissues. Although many amniotic fluid proteins have been identified and are currently used to detect potential fetal anomalies, little is known about the functions of these proteins and how they interact with one another. Identification of changes in the protein content of amniotic fluid, therefore, may be used to detect a particular type of pathology, or to ascertain a specific genetic disorder. In the present work we used a proteomic approach, combining 2DE and MS, in order to study the protein composition of AFS.

Item Type: Article
Uncontrolled Keywords: Proteomic analysis, amniotic fluid, protein
Subjects: 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 618 Altri rami della medicina; Ginecologia e ostetricia, Pediatria, Geriatria > 618.2 Ostetricia
Depositing User: Gianni Aiello
Date Deposited: 29 Apr 2013 13:47
Last Modified: 16 May 2013 12:17

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