Osteonecrosis of the myeloma patients treated with bisphosphonates

Capalbo, Silvana and Franzese, Maria Grazia and Palumbo, Gaetano (2007) Osteonecrosis of the myeloma patients treated with bisphosphonates. Clinical cases in mineral and bone metabolism, 4 (1). pp. 43-47. ISSN 1971-3266

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Osteonecrosis of the jaw (ONJ) has been reported as uncommon but well recognised complication associated with bisphosphonate treatment. Multiple Myeloma (MM) is the pathology most frequently associated with ONJ in the medical and dental papers published over the last years (45% of the ONJ published cases). ONJ appears to be time-dependent with higher risk after long-term use of intravenous (i.v.) nitrogen containing bisphosphonates (eg, pamidronate, zoledronate) in older MM patients. The most frequent site of ONJ is the mandible and previous dental procedures may be a precipitating factor. Most of the ONJ cases presented clinical evidence of bone exposure and pain. There was no significant association between the occurrence of ONJ and the presence of osteolytic lesions, disease status and the use of thalidomide. Different treatments have been proposed, associated or not: medical therapy (eg, antimicrobial oral rinses, antibiotic and antimicotic), surgical therapy (eg, curettage or sequestrectomy) showing low healing rates and uncertain impact on the prognosis and on the outcome

Item Type: Article
Uncontrolled Keywords: Osteonecrosis, multiple myeloma, bisphosphonates
Subjects: 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 612 Fisiologia umana > 612.7 Sistema muscoloscheletrico, tegumento
Depositing User: Danilo Dezzi
Date Deposited: 20 Jan 2014 10:21
Last Modified: 20 Jan 2014 10:21
URI: http://eprints.bice.rm.cnr.it/id/eprint/4808

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