Calcitonin and calcitonin receptors

Masi, Laura and Brandi, Maria Luisa (2007) Calcitonin and calcitonin receptors. Clinical cases in mineral and bone metabolism, 4 (2). pp. 117-122. ISSN 1971-3266

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Abstract

Calcitonin (CT) is a polypeptide hormone with 32 aminoacids syntetized primarily by the thyroid. Several evidences support the existence of nonthyroidal CT like peptide. The CT gene transcript also encodes a distinct peptide known as calcitonin gene related peptide (CGRP) which is a potent vasodilator and responsible for the stimulation of theglomerular filtration rate. In addition, a 37 aminoacid peptideamylin has been originally isolated by pancreatic β-cells. Amylin is able to inhibit insulin secretion, glucose transport into the skeletal musculature and gluconeogenesis. It is also able to inhibit gastric emptying. In the kidney it is able to modulate Calcium (Ca2+) excretion and increases renin activity. Finally, high affinity amylin receptors have been identified in the brain of the rat. The calcitonin receptor (CTR) is a member of a subfamily of the seven-transmembrane domain G-protein coupled receptor super family that includes several peptides. Members of this family have a similar structure with other seven-membrane- spanning domain G-protein coupled receptors. The genetic contribution to osteoporosis susceptibility is well documented and many studies demonstrated that genetic factors play important roles in the regulation of bone metabolism. Restriction Fragment Length Polymorphisms (RFLPs) for the CTR gene have been described in the literature with a positive association with the lumbar bone mineral density (BMD), femoral neck BMD and with a lower incidence of vertebral fractures

Item Type:	Article
Uncontrolled Keywords:	Calcitonin, calcitonin receptor, calcitonin receptor polymorphisms, osteoporosis
Subjects:	600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 612 Fisiologia umana > 612.7 Sistema muscoloscheletrico, tegumento
Depositing User:	Danilo Dezzi
Date Deposited:	20 Jan 2014 10:04
Last Modified:	20 Jan 2014 10:04
URI:	http://eprints.bice.rm.cnr.it/id/eprint/4853

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