Genetics of cardiovascular disease

Abbate, Rosanna and Sticchi, Elena and Fatini, Cinzia (2008) Genetics of cardiovascular disease. Clinical cases in mineral and bone metabolism, 5 (1). pp. 63-66. ISSN 1971-3266

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Linkage studies and genome-wide linkage analyses, which use polymorphic DNA markers throughout the genome, provide a useful method for identifying genes related to cardiovascular disease (CVD). Many genome-wide linkage studies have contributed to identify quantitative genetic loci influencing variables involved in the pathogenesis of CVD. Meta-analyses of genetic studies provide the measure of association studies, so contributing to identify candidate genes which might influence the susceptibility to the disease. Really, candidate genes have been investigated, in relation to lipid metabolism (APOE), fibrinolytic proteins (PAI-1), renin-angiotensyn system (ACE) and homocysteine metabolism (MTHFR). Recently, genome-wide panels of common single nucleotide polymorphisms (SNPs), based on the use of SNPs spread throughout the genome, are also becoming available. This approach contributes to finely investigate the gene-gene and gene-environment interactions in CVD, and to look for the involvement of genetic polymorphisms in drug response.

Item Type: Article
Uncontrolled Keywords: Linkage studies, genome-wide association studies, genetic predisposition
Subjects: 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 612 Fisiologia umana > 612.7 Sistema muscoloscheletrico, tegumento
Depositing User: Danilo Dezzi
Date Deposited: 17 Jan 2014 10:14
Last Modified: 17 Jan 2014 12:10

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