Soluble molecules and bone metabolism in multiple myeloma: a review

Zoppoli, Gabriele and Balleari, Enrico and Ghio, Riccardo (2008) Soluble molecules and bone metabolism in multiple myeloma: a review. Clinical cases in mineral and bone metabolism, 5 (1). pp. 67-70. ISSN 1971-3266

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Bone metabolism and turnover are strongly altered in multiple myeloma, as a consequence of the proliferation of malignant cells resembling plasmacells in the bone marrow. By both direct or indirect secretion of several molecules, and cell-to-cell interactions, multiple myeloma cells lead to severe and disabling skeletal alterations, such as osteolytic lesions, pathologic fractures, and osteoporosis. In this review, we summarize the studies concerning the soluble molecules which are supposed to have a role in this pathological process. We then consider the substances that, either in serum or urine specimens, can be dosed in the affected patients, thus giving an indirect measure of their altered bone turnover. In the last part of our review, we discuss the potential action of the new antimyeloma drug bortezomib (Velcade®, Janssen-Cilag), in opposing and maybe reverting, through a possible direct “proosteoblastic” effect, the deranged bone turnover which characterizes this disabling and unavoidably deathly disease.

Item Type: Article
Uncontrolled Keywords: Multiple myeloma, bone, turnover, soluble, bortezomib
Subjects: 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 612 Fisiologia umana > 612.7 Sistema muscoloscheletrico, tegumento
Depositing User: Danilo Dezzi
Date Deposited: 17 Jan 2014 10:12
Last Modified: 17 Jan 2014 10:12

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