Pathogenesis of nephrolithiasis: recent insight from cell biology and renal pathology

Gambaro, Giovanni and Fabris, Antonia and Abaterusso, Cataldo and Cosaro, Alex and Ceol, Monica and Mezzabotta, Federica and Torregrossa, Rossella and Tiralongo, Emilia and Del Prete, Dorella and D’Angelo, Angela and Anglani, Franca (2008) Pathogenesis of nephrolithiasis: recent insight from cell biology and renal pathology. Clinical cases in mineral and bone metabolism, 5 (2). pp. 107-109. ISSN 1971-3266

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Abstract

Randall’s plaques are very common in idiopathic calcium-oxalate nephrolithiasis. These papillary plaques have an apatite mineral structure. While these calcium deposits are generally assumed to be secondary to a purely physico-chemical phenomenon, we advance the hypothesis that they form due to a truly ectopic biomineralization in the renal tissue, and that Henle’s loop epithelial cells, or pericyte-like interstitial cells, or papillary stem cells differentiating along a bone lineage might be involved.

Item Type:	Article
Uncontrolled Keywords:	CaOx renal stones, ectopic calcification, epithelial-mesenchymal transformation, papilla, Randall’s plaque
Subjects:	600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 612 Fisiologia umana > 612.7 Sistema muscoloscheletrico, tegumento
Depositing User:	Danilo Dezzi
Date Deposited:	17 Jan 2014 10:08
Last Modified:	17 Jan 2014 12:02
URI:	http://eprints.bice.rm.cnr.it/id/eprint/5104

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