Cortical excitability and neurology: insights intothe pathophysiology

Radwa, Badawy, and Loetscher, Tobias and Macdonell, Richard and Brodtmann, Amy (2012) Cortical excitability and neurology: insights intothe pathophysiology. Functional Neurology : New Trends in Interventional Neurosciences, XXVII (3). pp. 131-145. ISSN 0393-5264

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Abstract

Transcranial magnetic stimulation (TMS) is a techniquedeveloped to non-invasively investigate the integrity ofhuman motor corticospinal tracts. Over the last threedecades, the use of stimulation paradigms including sin-gle-pulse TMS, paired-pulse TMS, repetitive TMS, and in-tegration with EEG and functional imaging have been de-veloped to facilitate measurement of cortical excitability.Through the use of these protocols, TMS has evolved in-to an excellent tool for measuring cortical excitability.TMS has high sensitivity in detecting subtle changes incortical excitability, and therefore it is also a good meas-ure of disturbances associated with brain disorders. Inthis review, we appraise the current literature on corticalexcitability studies using TMS in neurological disorders.We begin with a brief overview of current TMS measuresand then show how these have added to our understand-ing of the underlying mechanisms of brain disorders.

Item Type: Article
Subjects: 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.8 Malattie del sistema nervoso e disturbi mentali (Classificare qui la Neuropsichiatria, la Neurologia)
Depositing User: Chiara Bisogno
Date Deposited: 10 Sep 2019 12:50
Last Modified: 10 Sep 2019 14:43
URI: http://eprints.bice.rm.cnr.it/id/eprint/5174

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