Thrombophilia and damage of kidney during pregnancy

Larciprete, Giovanni and Liumbruno, Giancarlo Maria and Rongioletti, Mauro and Montagnoli, Carlotta and Rossi, Federica and Papa, Fabrizio and Jarbis, Shevas and Di Pierro, Giuseppe and Bompiani, Alessandro and Cirese, Elio and Valensise, Herbert (2011) Thrombophilia and damage of kidney during pregnancy. Journal of prenatal medicine, 5 (4). pp. 78-82. ISSN 1971-3290

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Abstract

Objectives: It’s known that heritable thrombophilias are a risk factor for the development of obstetrics complications associated to inadequate uterine-placental circulation, as pre-eclampsia/eclampsia, HELLP syndrome, placental abruption and intrauterine growth restriction (IUGR), however it was never investigated the role that they could have in the renal failure associated to such conditions. The purpose of this study is to evaluate if thrombophilia itself that predispose to a possible renal damage or if its occurrence determines a more severe involvement of the kidneys in the course of these obstetric pathologies. Methods: In the study were enrolled 301 pregnant women, who carried a thrombophilic state, 125 of whom (B group) has had an obstetric complication. In all the women the renal function was assessed taking into consideration proteinuria, creatininaemia and hypalbuminaemia. Results: Of the three parameters which have been considered as evidence of a severe renal involvement the hypalbuminaemia appears statistically significant compared to the controls. Even creatinaemia is significantly increased in pregnant women with an Anthithrombin deficiency, and increased levels are detected in women with Factor V Leiden. Conclusions: In obstetric complications associated to thrombophilic state could be a more severe involvement of the kidney.

Item Type:	Article
Uncontrolled Keywords:	Obstetric complications, renal damage in pregnancy, heritable thrombophilias
Subjects:	600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 618 Altri rami della medicina; Ginecologia e ostetricia, Pediatria, Geriatria > 618.3 Malattie e complicazioni della gravidanza
Depositing User:	Gianni Aiello
Date Deposited:	28 May 2013 16:09
Last Modified:	28 May 2013 16:09
URI:	http://eprints.bice.rm.cnr.it/id/eprint/5218

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